protective effect of johne’s disease attenuated vaccine in an intensive non-tuberculosis free dairy

Protective effect of Johne’s disease attenuated vaccine in an intensive non-tuberculosis free dairy

This study was carried out to control Johne’s disease (JD) without interfering with tuberculosis (TB)control programme. A dairy herd (n>1500 heads) was used over a period of 6 years, from 1994 to 1999 forthis investigation. The herd had a history of heavy infection with Mycobacterium avium paratuberculosis(MAP) with culling rates of 1.5 and 5%, in 1991 and 1995, respectively. The mean annual lo...

An attenuated Salmonella-vectored vaccine elicits protective immunity against Mycobacterium tuberculosis.

There is a need to develop protective vaccines against tuberculosis (TB) that elicit full immune responses including mucosal immunity. Here, a live attenuated Salmonellatyphimurium aroA SL7207 vector TB vaccine, namely SL(E6-85B), harboring the Mycobacterium tuberculosis (M. tb) H37Rv ESAT6-Ag85B fusion gene was developed. The experimental data demonstrated that this SL(E6-85B) vaccine, or when...

Development of an Attenuated Live Virus Vaccine against Sheep Pox

[BCG vaccine against tuberculosis: its protective effect and vaccination policies].

OBJECTIVE The BCG vaccine has been in use since 1921, but still arouses controversy and uncertainties. The objective was to analyze the protective effect of the BCG vaccine in its first and second doses and the accompanying vaccination policies. METHODS A systematic review of the literature in both English and Spanish was carried out, covering the period 1948 to 2006, using the PubMed databas...

Accidental self-inoculation in a veterinarian with attenuated vaccine of bovine Johne’s disease

Herein, we described the first case of self-inoculation in a veterinarian with bovine Johne’s disease(BJD) attenuated vaccine in Iran that required medical attention. A needle-stick injury to the right thumb of ayoung veterinarian during vaccination of cattle with BJD vaccine resulted in an inflammation that not onlyfailed to resolve but also progressed to a lesion 2.5 cm in diameter. The usual...

Protective Efficacy of Centralized and Polyvalent Envelope Immunogens in an Attenuated Equine Lentivirus Vaccine

Lentiviral Envelope (Env) antigenic variation and related immune evasion present major hurdles to effective vaccine development. Centralized Env immunogens that minimize the genetic distance between vaccine proteins and circulating viral isolates are an area of increasing study in HIV vaccinology. To date, the efficacy of centralized immunogens has not been evaluated in the context of an animal...